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Aralast (Baxter): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Aralast (Baxter) - General Information

Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.

 

Pharmacology of Aralast (Baxter)

Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema.

 

Aralast (Baxter) for patients

 

Aralast (Baxter) Interactions

 

Aralast (Baxter) Contraindications

Zemaira™ is contraindicated in individuals with a known hypersensitivity to any of its components. Zemaira™ is also contraindicated in individuals with a history of anaphylaxis or severe systemic response to A1-PI products. Individuals with selective IgA deficiencies who have known antibodies against IgA (anti-IgA antibodies) should not receive Zemaira™, since these patients may experience severe reactions, including anaphylaxis, to IgA that may be present in Zemaira™.

 

Additional information about Aralast (Baxter)

Aralast (Baxter) Indication: For treatment of panacinar emphysema Mechanism Of Action: Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). It primarily inhibits the action of the serine protease called elastase (also plasmin and thrombin). The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Alpha-1-proteinase inhibitor Synonyms: Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin precursor; Alpha 1-antitrypsin Drug Category: Enzyme Replacement Agents Drug Type: Biotech; Approved Other Brand Names containing Alpha-1-proteinase inhibitor: Aralast (Baxter); Prolastin (Talecris Biotherapeutics C formerly Bayer); Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Aralast (Baxter): Injection, powder, lyophilized, for solution Intravenous Chemical IUPAC Name: Alpha-1-proteinase inhibitor Chemical Formula: C2001H3130N514O601S10 Alpha-1-proteinase inhibitor on Wikipedia: https://en.wikipedia.org/wiki/Alpha_1-antitrypsin Organisms Affected: Humans and other mammals